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NU T R I T I ON
Fish-Oil Supplements
Offer Health Benefits for Some Conditions
More than 50 percent of adults in the United
States use dietary supplements, and fish oil is
among the most popular. Although scientific
evidence suggests that consuming fish-oil
supplements to increase dietary intake of
omega-3 fatty acids may safely and effectively
provide specific health benefits for certain
conditions, experts caution that fish-oil
supplements are not a cure-all.
“There is no question that fish oil has been
effective in reducing high triglycerides, which
are associated with heart disease and poorly
controlled diabetes,” explains cardiologist
Gregg C. Fonarow, MD, co-director of
the UCLA Cholesterol, Hypertension and
Atherosclerosis Management Program
(CHAMP). According to Dr. Fonarow, the
right dose to reduce triglycerides, or fats
related to cholesterol in the blood, is about
two-to-four grams daily.
Fish-oil supplementation may also provide
some benefit to patients with heart failure,
Dr. Fonarow says. Recent studies suggest,
however, it does not lower the risk for first or
recurrent heart attacks among people with,
or at high risk for, heart disease, particularly
those who already take cholesterol-lowering
statins. There is also conflicting evidence as to
whether fish-oil supplementation is associated
UCLAHEALTH.ORG 1-800-UCLA-MD1 (1-800-825-2631)
with a lower risk for high blood pressure,
diabetes, stroke or cardiac death.
“Fish oil is not a panacea,” Dr. Fonarow
emphasizes. “Although fish-oil supplements
are generally safe and well-tolerated when used
correctly, it does not make up for significant
risk factors or unhealthy lifestyle behaviors,
such as smoking.”
Fish-oil supplementation may also benefit
people with diagnosed depression, bipolar
disorder and certain other mental illnesses,
says UCLA psychiatrist Peter Dell, MD. But
evidence about its effectiveness is mixed.
“We have more robust evidence for the
effectiveness of standard Western medicines in
patients with depression or bipolar disorders,”
Dr. Dell explains. “But for patients who don’t
want to use standard Western medicine,
I will usually consider prescribing fish-oil
supplements because it can sometimes be
effective with very few side effects.” He adds
that the best evidence points to using fish
oil in combination with standard Western
medicines such as antidepressants rather than
alone. He recommends that people should
ask their doctors if fish-oil supplementation
is appropriate for their condition.
“If fish oil is cleared by their doctors, they
should take 1,000 to 2,000 milligrams per
day and make sure at least 60 percent of the
omega-3 fatty acids in the supplements are
EPA,” he says. Two of the most important
omega-3 fatty acids contained in fish
oil are eicosapentaenoic acid (EPA) and
docosahexaenoic acid (DHA). “DHA does
not appear to be helpful for mood, and may
actually worsen problems,” Dr. Dell says.
Fish oil also has demonstrated effectiveness
outside of cardiovascular and mental health.
In children with intestinal failure, for example,
fish oil is safe and effective in helping to
reverse liver disease and may also decrease the
need for liver and/or intestinal transplants, as
well as mortality, recent studies have shown.
Although most experts say fish oil is
likely safe for most people, including
pregnant women and those who are breast-
feeding, when taken in low doses, high
doses should be taken only while under
medical supervision. Many health experts
recommend that people try to eat a healthy,
balanced diet to protect against diseases and
most cancers, and turn to supplements for
extra help only when necessary.